AffiNANOTECH® Thailanstatin A

Availables Sizes: 1 mg, 5 mg, 10 mg, 50 mg, 100 mg.

Overview

Thailanstatin A is an ultra-potent inhibitor of eukaryoticRNA splicing (IC50=650 nM) . Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiplecancercell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC.