AffiNANOTECH® Izeltabart

Availables Sizes: 1 mg, 5 mg, 10 mg, 50 mg, 100 mg.

Overview

Izeltabart is a high-affinity humanized antibody targetingADAM9. Izeltabart can be used asADC Antibodyfor site-specific conjugation with Maytansinoid-based DM21-C (aDrug-Linker Conjugates for ADC), to synthesize IMGC936 (Antibody-Drug Conjugates (ADCs) ) with strong anti-cancer activity. DM21-C is composed of Maytansinoid (microtubule inhibitor) and a stable tripeptide linker. IMGC936 exhibits cytotoxicity against ADAM9-positive human tumor cell lines and potent antitumor activity in xenograft tumor models.