AffiNANOTECH® Methyltetrazine-DBCO

Availables Sizes: 50 mg, 100 mg, 250 mg.

Overview

Methyltetrazine-DBCO is a non-cleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs) . Methyltetrazine-DBCO is aclick chemistryreagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.