AffiNANOTECH® N3-PEG8-Phe-Lys-PABC-Gefitinib

Availables Sizes: 50 mg, 100 mg, 250 mg.

Overview

N3-PEG8-Phe-Lys-PABC-Gefitinib is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-tumor agent, Gefitinib (orally activeEGFRtyrosine kinase inhibitor), linked via thecleavable linkerN3-PEG8-Phe-Lys-PABC. N3-PEG8-Phe-Lys-PABC-Gefitinib is aclick chemistryreagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.