AffiNANOTECH® MC-GGFG-AM- (10Me-11F-Camptothecin)
CAT# AFG-MCX-1350
Size: 100 mg
Availables Sizes: 1 mg, 5 mg, 10 mg, 50 mg, 100 mg.
Overview
MC-GGFG-AM- (10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting humanGPC3. ZW251 consists of a humanizedIgG1antibody conjugated to a novel camptothecin-basedtopoisomerase1inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG) -aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negativecancercells.
Isotype
N/A.
Species
N/A.
Target
N/A.
Appearance
Solid.
Shipping Conditions
Room Temperature.
Storage Conditions
(-) 20°C, sealed storage, away from moisture and light. In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) .