AffiNANOTECH® NT1-O12B

Availables Sizes: 10 mM * 1 mL in DMSOready for reconstitution, 10 mM * 1 mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 500 mg.

Overview

NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB) -impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination.