Gene Delivery

Gene Delivery refers to the use of affinity-functionalized nanotechnology platforms tailored for the precise delivery of genetic material—such as plasmid DNA, mRNA, siRNA, or CRISPR components—to specific cells or tissues.

Technical Content and Mechanism

  • Nanocarrier Design for Gene Delivery:
    • Material Selection:
      Nanocarriers for gene delivery are often composed of biodegradable polymers (e.g., poly(lactic-co-glycolic acid) [PLGA], chitosan, polyethyleneimine [PEI]), lipid-based systems (liposomes, lipid nanoparticles), or inorganic nanoparticles (e.g., gold, silica). 
  • Affinity Functionalization:
    • Optimizing Ligand Display:
      The density, orientation, and spatial distribution of ligands are optimized to maximize binding to target cells while preventing steric hindrance, ensuring efficient receptor-mediated recognition and uptake.
  • Genetic Payload Loading and Protection:
    • Complexation or Encapsulation:
      Genetic material may be electrostatically complexed with cationic polymers or encapsulated within lipid or polymeric matrices. This protects nucleic acids from nuclease degradation and immune recognition during circulation.

Applications

  • Gene Therapy:
    Targeted delivery of therapeutic genes can correct genetic defects, treat cancers, or modulate disease-related pathways by introducing, silencing, or editing specific genes in affected tissues with high precision.
  • RNA-Based Therapies:
    Delivery of mRNA for protein replacement, siRNA for gene silencing, or CRISPR components for genome editing to specific cells can treat a variety of diseases, including genetic disorders, cancers, and viral infections, while minimizing off-target effects.
  • Vaccination and Immunotherapy:
    Delivery of genetic material encoding antigens directly into dendritic cells or other antigen-presenting cells can generate strong and specific immune responses, forming the basis of DNA/RNA vaccines and personalized immunotherapies.

Gene Delivery AffiNANOTECH leverages affinity-based targeting and sophisticated nanoparticle engineering to enable precise and efficient delivery of genetic materials to specific cells and tissues. 

AffiNANOTECH® Arg-Arg-Arg-Arg acetate
CAT# AFG-MCX-1634
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Arg-Arg-Arg-Arg
CAT# AFG-MCX-1633
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Tetralysine
CAT# AFG-MCX-1632
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® RALA peptide
CAT# AFG-MCX-1631
Size: 100 mg
0.00 0.0 USD
145.00 145.0 USD
AffiNANOTECH® Caraphenol A
CAT# AFG-MCX-1629
Size: 50 mg
0.00 0.0 USD
152.50 152.5 USD
AffiNANOTECH® DODAP hydrochloride
CAT# AFG-MCX-1627
Size: 100 mg
0.00 0.0 USD