Protein Delivery ​

Protein Delivery involves the application of affinity-functionalized nanotechnology to deliver therapeutic proteins with high precision and efficiency. By integrating affinity ligands onto nanocarriers designed for protein encapsulation or surface conjugation, this approach targets specific cells or tissues, protects protein integrity, enhances uptake, and controls release.

Technical Content and Mechanism

• Nanocarrier Design for Protein Delivery:
  • Material Selection:
    Nanocarriers for protein delivery are typically made from biodegradable polymers (e.g., PLGA, chitosan), lipids (forming liposomes or lipid nanoparticles), dendrimers, or inorganic materials (e.g., silica, gold). 
• Affinity Functionalization:
• • Optimization of Surface Presentation:
    The density and orientation of the ligands are optimized to maximize binding efficiency and target specificity, while avoiding steric hindrance and maintaining carrier stability.
• Protein Encapsulation and Protection:
  • Encapsulation Techniques:
    Proteins can be encapsulated within the core of polymeric nanoparticles or liposomes, adsorbed onto the surface, or conjugated to the carrier through cleavable linkers. Encapsulation protects proteins from proteolytic degradation, denaturation, and immune recognition.

Applications

• Enzyme Replacement Therapy:
  Delivering functional enzymes to cells with genetic deficiencies can restore metabolic balance, as seen in lysosomal storage disorders or other enzyme-deficiency diseases.
• Cancer Therapy:
  Targeted delivery of therapeutic proteins—such as apoptosis-inducing factors, immune modulators, or angiogenesis inhibitors—directly to tumor cells or the tumor microenvironment can enhance cancer treatment efficacy while reducing systemic toxicity.
• Regenerative Medicine:
  Proteins like growth factors, cytokines, or extracellular matrix components can be delivered to specific tissues to promote cell growth, differentiation, and tissue repair.

Protein Delivery AffiNANOTECH leverages affinity-based targeting and sophisticated nanocarrier engineering to enhance the delivery of therapeutic proteins. By optimizing carrier composition, surface functionalization, encapsulation methods, and release mechanisms, this approach improves targeting precision, protects protein integrity, and ensures controlled delivery.