Antibody Drug Conjugate

Antibody–drug conjugates (ADCs) constitute a class of targeted biotherapeutics that combine the specificity of monoclonal antibodies with the potency of cytotoxic small molecules. The ADC platform aims to increase therapeutic index by selectively delivering a cytotoxic payload to antigen-expressing cells, thereby minimizing off-target effects relative to conventional chemotherapy.

Composition and Technical Content

An ADC is structurally composed of three critical elements:

  • Monoclonal Antibody (mAb):
    • Selection Criteria: The antibody is chosen for high affinity and specificity toward a tumor-associated antigen, with minimal expression in normal tissues.
  • Cytotoxic Payload:
    • Properties: Payloads are highly potent small-molecule drugs that generally exhibit sub-nanomolar activity. Common classes include auristatins (e.g., monomethyl auristatin E, MMAE), maytansinoids (e.g., DM1), and pyrrolobenzodiazepine (PBD) dimers.
  • Linker Chemistry:
    • Design Criteria: The linker must be chemically stable in systemic circulation yet cleavable under specific intracellular conditions. Cleavable linkers may be pH-sensitive, enzyme-sensitive, or reducible via disulfide bonds. Non-cleavable linkers rely on complete proteolytic degradation of the antibody to release the active drug.

Applications

  • Oncology: ADCs are primarily applied in cancer treatment. They offer targeted delivery of cytotoxic agents to tumor cells while sparing normal tissues, thus reducing systemic toxicity. 
  • Therapeutic Window: The optimization of ADCs involves balancing stability in circulation, efficient internalization, and effective payload release to maximize the therapeutic window.
  • Clinical Development and Challenges: Ongoing research focuses on enhancing ADC stability, improving site-specific conjugation techniques, designing novel payloads with different mechanisms of action, and identifying new tumor-associated antigens. 

ADCs represent a convergence of immunology, chemistry, and pharmacology to deliver potent cytotoxic agents selectively to diseased cells. Their design relies on precise engineering of antibodies, linkers, and payloads, forming a sophisticated yet focused therapeutic modality that aims to improve cancer treatment outcomes with reduced systemic side effects.

AffiNANOTECH® (Ac) Phe-Lys (Alloc) -PABC-PNP
CAT# AFG-MCX-1357
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Ladiratuzumab
CAT# AFG-MCX-1356
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Idactamab
CAT# AFG-MCX-1355
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Vadastuximab
CAT# AFG-MCX-1354
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Tusamitamab
CAT# AFG-MCX-1353
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Dap-NE hydrochloride
CAT# AFG-MCX-1352
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® MC-VC-PABC-amide-PEG1-CH2-CC-885
CAT# AFG-MCX-1351
Size: 100 mg
0.00 0.0 USD
0.00 0.0 USD
AffiNANOTECH® N3-PEG8-Phe-Lys-PABC-Gefitinib
CAT# AFG-MCX-1349
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® N3-PEG3-vc-PAB-MMAE
CAT# AFG-MCX-1348
Size: 100 mg
6,017.00 6017.0 USD
AffiNANOTECH® N3-PEG3-VC-PAB-MMAF
CAT# AFG-MCX-1347
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Azido-PEG4-Val-Cit-PAB-MMAE
CAT# AFG-MCX-1346
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Propargyl-PEG3-acid
CAT# AFG-MCX-1345
Size: 100 mg
112.00 112.0 USD
AffiNANOTECH® (S, R, S) -MI-1061
CAT# AFG-MCX-1344
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® DBCO-PEG4-Ahx-DM1
CAT# AFG-MCX-1343
Size: 1 mg
3,872.00 3872.0 USD
AffiNANOTECH® Cofetuzumab pelidotin
CAT# AFG-MCX-1342
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® DIBAC-GGFG-NH2CH2-Dxd
CAT# AFG-MCX-1341
Size: 100 mg
12,749.00 12749.0 USD
AffiNANOTECH® N3-PEG4-C2-Pfp ester
CAT# AFG-MCX-1340
Size: 100 mg
415.00 415.0 USD
AffiNANOTECH® N3-PEG3-C2-PFP ester
CAT# AFG-MCX-1339
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® N3-PEG3-C2-NHS ester
CAT# AFG-MCX-1338
Size: 100 mg
220.00 220.0 USD
AffiNANOTECH® N3-PEG2-C2-PFP ester
CAT# AFG-MCX-1337
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® N3-PEG2-C2-NHS ester
CAT# AFG-MCX-1336
Size: 100 mg
250.00 250.0 USD
0.00 0.0 USD
0.00 0.0 USD
0.00 0.0 USD
AffiNANOTECH® Py-MAA-Val-Cit-PAB-MMAE
CAT# AFG-MCX-1332
Size: 100 mg
7,089.50 7089.5 USD
1,314.50 1314.5 USD
0.00 0.0 USD
1,562.00 1562.0 USD
0.00 0.0 USD
AffiNANOTECH® IMPDH2-IN-2
CAT# AFG-MCX-1327
Size: 100 mg
4,367.00 4367.0 USD
AffiNANOTECH® 2', 3'-cGAMP-C2-PPA
CAT# AFG-MCX-1326
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® PROTAC BRD4 Degrader-13
CAT# AFG-MCX-1325
Size: 100 mg
0.00 0.0 USD
0.00 0.0 USD
AffiNANOTECH® AN-12-H5 intermediate-1
CAT# AFG-MCX-1323
Size: 100 mg
400.00 400.0 USD
AffiNANOTECH® Tamrintamab
CAT# AFG-MCX-1322
Size: 1 mg
0.00 0.0 USD
AffiNANOTECH® Piericidin A
CAT# AFG-MCX-1321
Size: 1 mg (12.03 mM * 200 μL in Ethanol)
745.00 745.0 USD
AffiNANOTECH® Gemtuzumab
CAT# AFG-MCX-1320
Size: 50 mg
0.00 0.0 USD
AffiNANOTECH® BCN-HS-PEG2-VA-PABC-SG3199
CAT# AFG-MCX-1319
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Mirzotamab
CAT# AFG-MCX-1318
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® DBCO-NHS ester 3
CAT# AFG-MCX-1317
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® DC1SMe
CAT# AFG-MCX-1316
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® MPO-IN-6
CAT# AFG-MCX-1315
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® L2H2-6OTD intermediate-3
CAT# AFG-MCX-1314
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® L2H2-6OTD intermediate-1
CAT# AFG-MCX-1313
Size: 100 mg
8,112.50 8112.5 USD
AffiNANOTECH® PBD dimer-2
CAT# AFG-MCX-1312
Size: 100 mg
9,152.00 9152.0 USD
AffiNANOTECH® DBCO-PEG4-MMAF
CAT# AFG-MCX-1311
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® DBCO-PEG4-VA-PBD
CAT# AFG-MCX-1310
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® PROTAC NAMPT Degrader-1
CAT# AFG-MCX-1309
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Tusamitamab ravtansine
CAT# AFG-MCX-1308
Size: 50 mg
0.00 0.0 USD
AffiNANOTECH® DC4SMe
CAT# AFG-MCX-1307
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® DC44SMe
CAT# AFG-MCX-1306
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Auristatin F-d8
CAT# AFG-MCX-1305
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® SMD-3040 intermediate-2
CAT# AFG-MCX-1304
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT
CAT# AFG-MCX-1303
Size: 50 mg
0.00 0.0 USD
AffiNANOTECH® Mc-Val-Cit-PAB-Cl
CAT# AFG-MCX-1302
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® MMAF-OMe
CAT# AFG-MCX-1301
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Azido-PEG2-C2-amine
CAT# AFG-MCX-1300
Size: 100 mg
145.00 145.0 USD
AffiNANOTECH® N3-PEG3-CH2CH2COOH
CAT# AFG-MCX-1299
Size: 100 mg
190.00 190.0 USD
AffiNANOTECH® Anticancer agent 81
CAT# AFG-MCX-1297
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® DBCO-NHS ester 2
CAT# AFG-MCX-1296
Size: 100 mg
805.00 805.0 USD
0.00 0.0 USD
AffiNANOTECH® Mirvetuximab soravtansine (solution)
CAT# AFG-MCX-1294
Size: 1 mg(10.246 mg/mL * 97.6 μL in 10mM Histidine pH=5.5)
1,644.50 1644.5 USD
AffiNANOTECH® McMMAF
CAT# AFG-MCX-1293
Size: 100 mg
0.00 0.0 USD
0.00 0.0 USD
AffiNANOTECH® Succinic anhydride-13C2
CAT# AFG-MCX-1291
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Patritumab deruxtecan
CAT# AFG-MCX-1290
Size: 50 mg
0.00 0.0 USD
AffiNANOTECH® Iladatuzumab
CAT# AFG-MCX-1289
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 4-Pentynoyl-Val-Ala-PAB-PNP
CAT# AFG-MCX-1288
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® DM4-SMe
CAT# AFG-MCX-1287
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® MC-SN38
CAT# AFG-MCX-1286
Size: 100 mg
5,687.00 5687.0 USD
AffiNANOTECH® PNU-159682 carboxylic acid
CAT# AFG-MCX-1285
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Aniline-MPB-amino-C3-PBD
CAT# AFG-MCX-1284
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® M3554
CAT# AFG-MCX-1283
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® MMAF sodium
CAT# AFG-MCX-1282
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® MMAF
CAT# AFG-MCX-1281
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Tisotumab vedotin
CAT# AFG-MCX-1280
Size: 50 mg
0.00 0.0 USD
AffiNANOTECH® Camidanlumab
CAT# AFG-MCX-1279
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Nampt-IN-10 TFA
CAT# AFG-MCX-1278
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Mal-PEG8-Val-Ala-PAB-Exatecan
CAT# AFG-MCX-1277
Size: 100 mg
6,677.00 6677.0 USD
AffiNANOTECH® PROTAC ER Degrader-2
CAT# AFG-MCX-1276
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Mensacarcin
CAT# AFG-MCX-1275
Size: 1 mg
610.00 610.0 USD
AffiNANOTECH® PROTAC ER Degrader-3
CAT# AFG-MCX-1274
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® DM3-SMe
CAT# AFG-MCX-1273
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® PROTAC ERα Degrader-5
CAT# AFG-MCX-1272
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Fmoc-Gly-NH-CH2-acetyloxy
CAT# AFG-MCX-1271
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Mecbotamab
CAT# AFG-MCX-1270
Size: 1 mg
0.00 0.0 USD
AffiNANOTECH® β-Amanitin
CAT# AFG-MCX-1269
Size: 1 mg
1,727.00 1727.0 USD
AffiNANOTECH® Succinic anhydride-d4
CAT# AFG-MCX-1268
Size: 100 mg
160.00 160.0 USD
AffiNANOTECH® MC-Gly-Gly-Phe-Gly-GABA-Exatecan
CAT# AFG-MCX-1267
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Labetuzumab govitecan
CAT# AFG-MCX-1266
Size: 50 mg
0.00 0.0 USD
AffiNANOTECH® NH2-C5-PEG4-N3-L-Lysine-PEG3-N3
CAT# AFG-MCX-1265
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® MB076
CAT# AFG-MCX-1264
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Gemtuzumab ozogamicin
CAT# AFG-MCX-1263
Size: 100 μg
2,552.00 2552.0 USD
AffiNANOTECH® Trastuzumab emtansine
CAT# AFG-MCX-1262
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Dolastatin 15
CAT# AFG-MCX-1261
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Deruxtecan-d4
CAT# AFG-MCX-1260
Size: 1 mg
0.00 0.0 USD
AffiNANOTECH® Deruxtecan-d5
CAT# AFG-MCX-1259
Size: 100 mg
0.00 0.0 USD
0.00 0.0 USD