LNP 

LNP AffiNANOTECH" refers to the integration of affinity-based targeting strategies with lipid nanoparticle (LNP) technology. LNPs are versatile, nanoscale delivery vehicles composed of lipids that encapsulate therapeutic agents like nucleic acids, small molecules, or proteins. By functionalizing their surfaces with affinity ligands—such as antibodies, peptides, or aptamers—these nanoparticles can specifically target and deliver payloads to selected cells or tissues.

Technical Content and Mechanism

  • Lipid Nanoparticle (LNP) Desig
      Size and Morphology:
      LNPs are engineered to be within the range of 50–150 nm in diameter. The size affects biodistribution, cellular uptake, and ability to penetrate tissues. Techniques such as microfluidic mixing or ethanol injection are used to produce uniform LNPs with high encapsulation efficiency.
  • Affinity Functionalization:
      Surface Modification with Affinity Ligands:
      The outer surface of LNPs can be modified with affinity ligands that target specific receptors on the surface of desired cell types. This is often achieved by incorporating functionalized PEG-lipids bearing reactive groups (e.g., maleimide, NHS-esters) that allow covalent attachment of targeting moieties like antibodies, peptides, or aptamers.
  • Encapsulation and Protection of Payload:
      Loading of Therapeutic Agents:
      LNPs excel at encapsulating hydrophilic nucleic acids (e.g., mRNA, siRNA, CRISPR components) within their core, protecting these sensitive molecules from degradation by nucleases in biological fluids.

Applications

  • Gene Therapy and Vaccination:
    Affinity-targeted LNPs can deliver mRNA vaccines, siRNA therapeutics, or CRISPR gene-editing components to specific cell types, enhancing therapeutic efficiency while minimizing side effects. This has been notably impactful in mRNA vaccine delivery, where targeted LNPs can improve immune responses.
  • Cancer Treatment:
    LNPs functionalized with tumor-specific ligands can deliver chemotherapeutic agents or gene therapies directly to cancer cells, increasing local drug concentration and reducing harm to healthy tissue.
  • Personalized Medicine:
    By modifying the affinity ligand based on patient-specific markers, LNP AffiNANOTECH platforms can be tailored for individualized treatment regimens, improving therapeutic outcomes for conditions like genetic disorders or heterogeneous tumors.

LNP AffiNANOTECH leverages the intrinsic advantages of lipid nanoparticles—such as high payload capacity, biocompatibility, and efficient cellular delivery—while adding a layer of precision targeting through affinity ligand functionalization.

AffiNANOTECH® Firefly luciferase circRNA-LNP
CAT# AFG-MCX-1745
Size: 1 mg
0.00 0.0 USD
AffiNANOTECH® Firefly luciferase mRNA-LNP
CAT# AFG-MCX-1744
Size: 1 mg
0.00 0.0 USD
0.00 0.0 USD
0.00 0.0 USD
AffiNANOTECH® 18:1 PEG5000 PE
CAT# AFG-MCX-1741
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 18:1 PEG3000 PE
CAT# AFG-MCX-1740
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 18:1 PEG1000 PE
CAT# AFG-MCX-1739
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 18:1 PEG550 PE
CAT# AFG-MCX-1738
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 18:1 PEG350 PE
CAT# AFG-MCX-1737
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 14:0 PEG5000 PE
CAT# AFG-MCX-1736
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 14:0 PEG3000 PE
CAT# AFG-MCX-1735
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 14:0 PEG1000 PE
CAT# AFG-MCX-1734
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 14:0 PEG750 PE
CAT# AFG-MCX-1733
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 14:0 PEG550 PE
CAT# AFG-MCX-1732
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 14:0 PEG350 PE
CAT# AFG-MCX-1731
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 18:0 mPEG5000 PE ammonium
CAT# AFG-MCX-1730
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 18:0 mPEG3000 PE ammonium
CAT# AFG-MCX-1729
Size: 10 mg
0.00 0.0 USD
AffiNANOTECH® 18:0 mPEG1000 PE ammonium
CAT# AFG-MCX-1728
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 16:0 PEG5000 PE
CAT# AFG-MCX-1727
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 16:0 PEG3000 PE
CAT# AFG-MCX-1726
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 16:0 PEG1000 PE
CAT# AFG-MCX-1725
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 18:0 mPEG750 PE ammonium
CAT# AFG-MCX-1724
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 18:0 mPEG550 PE ammonium
CAT# AFG-MCX-1723
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 18:0 mPEG350 PE ammonium
CAT# AFG-MCX-1722
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 16:0 PEG750 PE
CAT# AFG-MCX-1721
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 16:0 PEG550 PE
CAT# AFG-MCX-1720
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 16:0 PEG350 PE
CAT# AFG-MCX-1719
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® ALC-0315 analogue-2
CAT# AFG-MCX-1718
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® PEG2000-DMPE
CAT# AFG-MCX-1717
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® C12-113
CAT# AFG-MCX-1716
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® C12-200
CAT# AFG-MCX-1715
Size: 100 mg
3,542.00 3542.0 USD
0.00 0.0 USD
AffiNANOTECH® C13-113-tri-tail
CAT# AFG-MCX-1713
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® C13-113-tetra-tail
CAT# AFG-MCX-1712
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® C13-112-tri-tail
CAT# AFG-MCX-1711
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® C13-112-tetra-tail
CAT# AFG-MCX-1710
Size: 1 mg
160.00 160.0 USD
AffiNANOTECH® Diamino lipid DAL4
CAT# AFG-MCX-1709
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® BP Lipid 378
CAT# AFG-MCX-1708
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Dios-Arg diTFA
CAT# AFG-MCX-1707
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 113-O16B
CAT# AFG-MCX-1706
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 113-O12B
CAT# AFG-MCX-1705
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® OF-C4-Deg-Lin
CAT# AFG-MCX-1704
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® DSPC (Excipient)
CAT# AFG-MCX-1703
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 113-N16B
CAT# AFG-MCX-1702
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® RCB-02-4-8
CAT# AFG-MCX-1701
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® DSPC
CAT# AFG-MCX-1700
Size: 100 mg
334.00 334.0 USD
AffiNANOTECH® NT1-O12B
CAT# AFG-MCX-1699
Size: 100 mg
3,377.00 3377.0 USD
AffiNANOTECH® G1-OC2-K3-E10
CAT# AFG-MCX-1698
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 50-C2-C9-4tail
CAT# AFG-MCX-1697
Size: 1 mg
329.50 329.5 USD
257.50 257.5 USD
AffiNANOTECH® Genevant CL1 monohydrochloride
CAT# AFG-MCX-1695
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® PEG2000-DGG
CAT# AFG-MCX-1694
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Genevant CL1
CAT# AFG-MCX-1693
Size: 100 mg
2,849.00 2849.0 USD
AffiNANOTECH® Lipid AX4
CAT# AFG-MCX-1692
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® C14-4
CAT# AFG-MCX-1691
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® CL4F8-6
CAT# AFG-MCX-1690
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® cKK-E15
CAT# AFG-MCX-1689
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® BP Lipid 135
CAT# AFG-MCX-1688
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® SQDG
CAT# AFG-MCX-1687
Size: 1 mg
670.00 670.0 USD
AffiNANOTECH® ATX-001
CAT# AFG-MCX-1686
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® NT1-014B
CAT# AFG-MCX-1685
Size: 100 mg
745.00 745.0 USD
AffiNANOTECH® 93-O17S
CAT# AFG-MCX-1684
Size: 100 mg
1,133.00 1133.0 USD
AffiNANOTECH® DNCA
CAT# AFG-MCX-1683
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® DSTAP chloride
CAT# AFG-MCX-1682
Size: 1 mg
190.00 190.0 USD
AffiNANOTECH® 306-O12B
CAT# AFG-MCX-1681
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 4A3-Cit
CAT# AFG-MCX-1680
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Lipid 14
CAT# AFG-MCX-1679
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® SM-102 (Excipient)
CAT# AFG-MCX-1678
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® OF-Deg-Lin
CAT# AFG-MCX-1677
Size: 1 mg
329.50 329.5 USD
AffiNANOTECH® SM-102
CAT# AFG-MCX-1676
Size: 100 mg
1,694.00 1694.0 USD
AffiNANOTECH® Lipid 8
CAT# AFG-MCX-1675
Size: 100 mg
2,222.00 2222.0 USD
AffiNANOTECH® Lipid 6
CAT# AFG-MCX-1674
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Lipid 15
CAT# AFG-MCX-1673
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Lipid 10
CAT# AFG-MCX-1672
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Lipid 1
CAT# AFG-MCX-1671
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® TCL053
CAT# AFG-MCX-1670
Size: 100 mg
2,634.50 2634.5 USD
AffiNANOTECH® MIC5
CAT# AFG-MCX-1669
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 244cis
CAT# AFG-MCX-1668
Size: 1 mg
175.00 175.0 USD
AffiNANOTECH® CLinDMA
CAT# AFG-MCX-1667
Size: 100 mg
5,357.00 5357.0 USD
AffiNANOTECH® ALC-0315 (Excipient)
CAT# AFG-MCX-1666
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® DLin-KC2-DMA
CAT# AFG-MCX-1665
Size: 100 mg
1,314.50 1314.5 USD
AffiNANOTECH® ALC-0315
CAT# AFG-MCX-1664
Size: 100 mg
1,100.00 1100.0 USD
AffiNANOTECH® CL4H6
CAT# AFG-MCX-1663
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Ionizable lipid-2
CAT# AFG-MCX-1661
Size: 100 mg
280.00 280.0 USD
AffiNANOTECH® 306Oi10
CAT# AFG-MCX-1660
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 18:0 DAP
CAT# AFG-MCX-1659
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 93-O17O
CAT# AFG-MCX-1658
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® C12-TLRa
CAT# AFG-MCX-1657
Size: 100 mg
2,469.50 2469.5 USD
AffiNANOTECH® Lipid C24
CAT# AFG-MCX-1656
Size: 5 mg
631.00 631.0 USD
AffiNANOTECH® Ionizable lipid-1 hydrochloride
CAT# AFG-MCX-1655
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Ionizable lipid-1
CAT# AFG-MCX-1654
Size: 100 mg
4,037.00 4037.0 USD
AffiNANOTECH® ssPalmM
CAT# AFG-MCX-1653
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® 9322-O16B
CAT# AFG-MCX-1652
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® Glucosamine Cholesterol
CAT# AFG-MCX-1651
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® CD19 car mRNA (Mouse) -LNP
CAT# AFG-MCX-1650
Size: 1 mg
0.00 0.0 USD
AffiNANOTECH® COVID-19 Spike Protein mRNA-LNP
CAT# AFG-MCX-1649
Size: 1 mg
0.00 0.0 USD
AffiNANOTECH® CD19 car circRNA-LNP
CAT# AFG-MCX-1648
Size: 1 mg
0.00 0.0 USD
AffiNANOTECH® 80-O16B
CAT# AFG-MCX-1647
Size: 100 mg
0.00 0.0 USD
AffiNANOTECH® eGFP circRNA-LNP
CAT# AFG-MCX-1646
Size: 1 mg
0.00 0.0 USD